IRON – HOW TOO MUCH IS BAD FOR YOU

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iron large

IRON IN YOUR SYSTEM

  1. INTAKE

  2. ABSORPTION

  3. STORAGE

  4. IRON REGULATION

  5. ELIMINATION

INTAKE

It comes from the food we eat, and supplements and multi vitamins we take.

Excess Iron is stored and iron is recycled from old hemoglobin through the spleen.

It also comes from iron added to food as a result of the law in the USA

By law in USA iron added to rice flour corn meal. It’s in commercial cereals.

 

 

WHAT IS IRON USED FOR

iron hemaglobin

 

A red protein responsible for transporting oxygen in the blood

Hemoglobin holds 80 percent of the bodies iron. Hemoglobin is the molecule used to carry oxygen. When hemoglobin’s needs and others are satisfied the ferritin stores the rest of the iron.

Iron accumulates with age. There isn’t a mechanism to get rid of it.

HOW MUCH IRON DO YOU NEED

You need 2 to 3 mg per day on average. If a woman is pregnant she needs a little more, if menstruating also a little more than normal

You need enough to satisfy the body’s needs and after that it will be in excess. When that happens it is not bound to anything and is called free iron. Any free iron will bind to ferritin, a protein molecule. This keeps the body safe, as excess iron is a very dangerous oxidizer. It creates a hydroxyl ion.

EXCESS IRON – HOW DO YOU KNOW WHEN YOU HAVE TO MUCH

Excess iron has no symptoms. You have to measure it in a hair analysis sample or a ferritin blood test.

WHAT ARE THE HEALTH AFFECTS

Excess iron leads to hydroxyl free radicals and inflammation

HOW DO YOU MEASURE IRON

Hair tissue mineral analysis

Ferritin tests ferritin levels roughly 40, to 60 to 80

Woman 20 to 40 ng/mi

Men          50 to    70 ng/mi

 

2 ABSORPTION

Sugar massively increases iron uptake in cells of the intestines

Iron comes into the stomach and goes through to the small intestine where it is absorbed. It comes in as fe3 ferric iron and gets absorbed as fe2 or ferrous iron.

An enzyme vitamin c ferri reductase allows Fe 3 to be turned into Fe 2 to be absorbed. It’s in the ferrous iron state that it’s absorbed into the intestine. After absorption it is oxidized back to ferric iron Fe 3 and stored as ferritin. Fe 2 is the form that is transported out of the intestine around the body to the liver and the bone marrow.

The enzyme hephaeitin turns it back into Fe 3 to be transported. In the blood iron needs to be transported around. It uses a protein carrier. Most of the iron is transported to the bone marrow to make red blood cells. Iron is used for haemoglobin to carry oxygen.

3 STORAGE

iron storage

 

 

10 to 20 percent of the iron goes to the liver. Stored in the ferric form as ferritin.

4.IRON REGULATION

Hepcidin is the master regulator. It is produced and secreted by the liver. It inhibits ferroportin the transporters that transport iron from the intestine to the blood where the iron is used for uses other than red blood cells. It decreases plasma iron concentration of iron from the intestine, also on the spleen macrophages. Hepcidin will block iron from the spleen coming back into the blood raising the concentration, after old blood cells have been recycled.

WHAT STIMULATES HEPPCIDIN PRODUCTION

Cytokines like interleukin 6 or in increase in plasma iron concentration. Polysaccharides LPS can stimulate production.  But the main one is the HFE protein from the liver. The HFE gene makes the HFE protein. The HFE protein interacts with other proteins to regulate iron absorption.

A mutation on the HFE gene results in a mutation in the HFE protein. Which results in hemochromatosis, which results in iron over load, too much iron in the tissues. If HFE protein does not work hepcidin will not work. The body will absorb a lot of iron from the intestine.

Iron also comes from red blood cells which is hemoglobin. Which can be broken down into heme and globin. Heme can be stored as ferritin.

WHAT CAUSES EXCESS IRON TO ACCUMULATE IN THE BODY

One thing that causes extra absorption is the amino acid methionine. It causes  iron to be greatly accumulated.

Birth control pills decrease blood flow and increase iron which accumulates and heart attacks go up. Serum iron levels follow circadian rhythms go up in the morning at 930 heart attacks go up.

Growth hormone increases the uptake of iron by decreasing the hormone hepcidin which controls iron uptake from food. Fasting increases hepcidin.

Refined carbs increase iron uptake. Hepcidin the hormone that controls iron absorption changes with sugar and carbs allows more iron to be absorbed, the result is oxidative stress, insulin resistance, and obesity.

WHAT STOPS IRON ABSORPTION

Green tea and coffee are some substances that stop absorption

Poly phenols stop iron accumulation green tea, curcumin, onions, bind to iron and remove it from the cells

Exercise lowers iron; exercise changes the iron uptake rate.

FREE IRON NEGATIVE RESULTS FOR THE BODY

Free iron leads to diabetes heart disease cancer Parkinson’s Alzheimer’s infections wrinkles gout kidney disease liver disease, blindness, macular degeneration, infections, aging.

Here’s the key negative reaction – in chemistry, it’s called Fenton’s reaction – where if you have excessive iron and that hydrogen peroxide is not going to water, it’s going to be catalyzed from hydroxyl free radical the most destructive free radical known to man, and in literally nanoseconds will decimate mitochondrial DNA, mitochondrial proteins, and cellular membranes. It will accelerate every major disease that we know. That’s how it causes the pathologies, especially in the liver and the cardiovascular disease you mentioned. That’s what causes the damage.

As we age free iron increases. Elevated levels of free radicals inside neurons and glia cells increase the release of free iron from ferritin molecules.

Iron in mitochondria of cells makes them function poorly.

Iron blocks arteries – damages lipids and other molecules result inflammation leads to plaque build up

Iron causes cancer, Ferritin fewer than 76 had a lower cancer risk. Iron up regulates cancer stem cells. Cancer stem cells are stem cells in cancer tumors that able to make other cancer cells. Iron is a ferrotoxic disease, meaning a disease that causes cancer. Iron promotes cancer by supressing the immune system.

Diabetes risks go up as iron ferritin goes up also risk for stroke.

Iron results in hydroxyl free radicals that causes damage to DNA that causes cancer.

Cancer uses iron and glucose for fuel

High iron results in 3x the risk of colon cancer, 1.5 x risks for lung cancer.

IRON CHELATORS LOWER CANCER RISK

Iron chelators are molecules that bond to iron and remove it.

CATECHINS cross blood brain barrier to chelate iron.

Ip6 & inositol taken with meals removes iron, taken between meals removes iron from blood and activates helper killer t cells to kill cancer and shrink tumors.

EGEC in curcumin and green tea chelate iron. You can take green tea capsules 200mg 3 xs per day. Eggs coffee, tea, no soda or orange juice.

Sweating will get rid of some iron, near infar red saunas.

IRON AND OXIDATIVE STRESS

Iron accumulates in the liver and the brain like copper.

The sun causes degradation of ferritin and the release of free iron causing oxidative stress

It affects dementia and Alzheimer’s. High iron = oxidative stress

Type 2 diabetes is a risk factor for type 3 diabetes. Type 2 causes disregulation of iron and allows for it to accumulate in the brain.   Iron results in insulin resistance and loss of insulin sensitivity.

Oxidative stress causes a loss of neurons that produce dopamine, more than the 13 percent that is normal per year. When dopamine decline s to 30 percent disease sets in and at 10 percent is death.

This sets a limit of lifespan

IRON FUNGAS AND BACTERIA

Most bacterial, all fungal and all protozoan pathogenic invaders require iron as an essential growth factor. Viruses use iron in the host cell for their reproduction.

Fungi are found in brains of Alzheimer’s patients. Fungus needs iron to grow.

IRON AND OBESITY

Iron up Leptin down it is the satiation hormone, it tells the body it’s full and does not need to eat anymore. When it goes down you eat more.

IRON AND THE LIVER

Iron is stored in the liver and causes nafld non-alcoholic fatty liver disease.

Nac helps fatty liver disease.

Alcohol causes alcoholic liver disease. Both together alcohol and iron is a bad combination.

Lipofuscin is the toxic junk of aging. Iron is a key player in accumulation of liposusion

Iron plus peroxide = lipofuscin. Free iron is what causes damage iron not bound to ferritin.

IRON AND HAIR ANALYSIS –HOW IRON CHANGES MAY AFFECT YOU

MENTAL TRAITS A PERSON CAN GO THROUGH CYCLING IRON

Iron gives physical and mental strength

Too much iron belligerence and hostile behaviour

To little iron indecisive unassertive

POSSIBLE HAIR COLOR CHANGES

Grey hair losing manganese and iron

AFFECTS BLOOD SUGAR

Iron up chromium down – this can affects blood sugar

High iron can lead to blood sugar problems and exhaustion

BLOOD AND HEMOGLOBIN

Too much or too little copper and iron can’t attach to hemoglobin

ENERGY

The right amount of iron is important for energy

INFECTION

Too much iron can lead to zinc deficiency and promote infection

 

HEMOCHROMATOSIS

When your iron no longer is under the control of  Hepcidin. One needs to give blood to lower the concentration of iron in the body. ferritin does not drop right after giving blood but as red blood cells are made more iron is needed and the amount of ferritin drops.

As we have seen a low carb,low iron or red meat diet, have chicken or fish instead. Eggs bind iron so eggs for breakfast is a good idea. Coffee chelates iron it must be drank with the meal. Also tea chelates as well. Coffee for breakfast tea for lunch.

Vitamin c strongly increases iron absorption so no orange juice. Vitamin c can be used but needs a special protocol with vitamin e. Also no soda as its mostly sugar.

No cooking using cast iron frying pans as well.

The amino acid  methionine raises iron absorption, as well as sugar does.  No sugar, also  with green tea , decaffeinated green tea, 200mg with each meal, curcumin, and ip6 with inositol,1000 mg between meals , don’t eat for an hour after. Quercetin would be useful to chelate iron.NAC. n- acetyl cysteine is the precursor to glutathione, the main anti oxidant, to protect you from oxidation.

With hemochromatosis

Get your hair mineral tissue analysis done to determine if you have any other toxic metal accumulation

Get ferritin and hemoglobin numbers checked to monitor iron storage.

Have a diet plan made up for you  to decrease iron storage

TAKEAWAY

Know your ferritin and hemoglobin numbers, know if you have  toxic metals there amounts and ratios.